Kyle Hadden, M.: search on Z-Library

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1

Repurposing the Clinically Efficacious Anti-Fungal Agent Itraconazole as an Anti-Cancer Chemotherapeutic

Pace, Jennifer R, DeBerardinis, Albert M, Sail, Vibhavari, Tacheva-Grigorova, Silvia K, Chan, Kelly A, Tran, Raymond, Raccuia, Daniel S, Wechsler-Reya, Robert J., Hadden, M. Kyle

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1.63 MB

english, 2016

2

SPIE Proceedings [SPIE Smart Structures and Materials - San Diego, CA (Sunday 14 March 2004)] Smart Structures and Materials 2004: Industrial and Commercial Applications of Smart Structures Technologies - Miniature vibration isolation system for space applications: Phase II

Jacobs, Jack H., Anderson, Eric H., Ross, James A., Hadden, Steve, Gonzalez, Mario, Rogers, Zach, Henderson, B. Kyle

Year:

2004

Language:

english

File:

PDF, 372 KB

english, 2004

3

The furan route to tropolones: probing the antiproliferative effects of β-thujaplicin analogs

Zachary Oblak, E., Bolstad, Erin S. D., Ononye, Sophia N., Priestley, Nigel D., Kyle Hadden, M., Wright, Dennis L.

Journal:

Organic & Biomolecular Chemistry

Year:

2012

Language:

english

File:

PDF, 382 KB

english, 2012

4

[Vitamins & Hormones] Vitamin D Hormone Volume 100 || Hedgehog and Vitamin D Signaling Pathways in Development and Disease

Hadden, M. Kyle

Year:

2016

Language:

english

File:

PDF, 1.19 MB

english, 2016

5

High-throughput screening for Hsp90 ATPase inhibitors

Christopher Avila, M. Kyle Hadden, Zeqiang Ma, Boris A. Kornilayev, Qi-Zhuang Ye, Brian S.J. Blagg

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 228 KB

english, 2006

6

A metadynamic approach to understand the recognition mechanism of the histone H3 tail with the ATRX ADD domain

Dash, Radha Charan, Zaino, Angela M., Kyle Hadden, M.

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms

Year:

2018

Language:

english

File:

PDF, 1.54 MB

english, 2018

7

A non-toxic Hsp90 inhibitor protects neurons from Aβ-induced toxicity

Sabah Ansar, Joseph A. Burlison, M. Kyle Hadden, Xiao Ming Yu, Kelly E. Desino, Jennifer Bean, Len Neckers, Ken L. Audus, Mary L. Michaelis, Brian S.J. Blagg

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 208 KB

english, 2007

8

Synthesis and Evaluation of Radamide Analogues, A Chimera of Radicicol and Geldanamycin

Hadden, M. Kyle, Blagg, Brian S. J.

Journal:

Journal of Organic Chemistry

Year:

2009

Language:

english

File:

PDF, 1.80 MB

english, 2009

9

Design, synthesis, and evaluation of hybrid vitamin D3 side chain analogues as hedgehog pathway inhibitors

Banerjee, Upasana, DeBerardinis, Albert M., Hadden, M. Kyle

Journal:

Bioorganic & Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 964 KB

english, 2015

10

Synthesis and evaluation of vitamin D3 analogues with C-11 modifications as inhibitors of Hedgehog signaling

Maschinot, Chad A., Hadden, M. Kyle

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2017

Language:

english

File:

PDF, 417 KB

english, 2017

11

Formulation and evaluation of itraconazole liposomes for Hedgehog pathway inhibition

Pace, Jennifer R., Jog, Rajan, Burgess, Diane J., Hadden, M. Kyle

Journal:

Journal of Liposome Research

Year:

2019

Language:

english

File:

PDF, 1.02 MB

english, 2019

12

Development of posaconazole-based analogues as hedgehog signaling pathway inhibitors

Teske, Kelly A., Dash, Radha Charan, Morel, Shana R., Chou, Lianne Q., Wechsler-Reya, Robert J., Hadden, M. Kyle

Journal:

European Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 2.75 MB

english, 2018

13

Synthesis and Evaluation of Derrubone and Select Analogues

Hastings, Jedidiah M., Hadden, M. Kyle, Blagg, Brian S. J.

Journal:

Journal of Organic Chemistry

Year:

2008

Language:

english

File:

PDF, 173 KB

english, 2008

14

Inhibition of the translesion synthesis polymerase REV1 exploits replication gaps as a cancer vulnerability

Nayak, Sumeet, Calvo, Jennifer A., Cong, Ke, Peng, Min, Berthiaume, Emily, Jackson, Jessica, Zaino, Angela M., Vindigni, Alessandro, Hadden, M. Kyle, Cantor, Sharon B.

Journal:

Science Advances

Year:

2020

File:

PDF, 4.79 MB

2020

15

Derrubone, an Inhibitor of the Hsp90 Protein Folding Machinery

Hadden, M. Kyle, Galam, Lakshmi, Gestwicki, Jason E., Matts, Robert L., Blagg, Brian S. J.

Journal:

Journal of Natural Products

Year:

2007

Language:

english

File:

PDF, 366 KB

english, 2007

16

Asymmetric Synthesis of ω-Bromo-2(S)-methyl Acids as Precursors for Novel Arginine, Lysine, and Mercapto Residues.

M. Kyle Hadden, Kyle P. Kokko, Thomas A. Dix

Journal:

Year:

2005

File:

PDF, 18 KB

2005

17

Viridin analogs derived from steroidal building blocks

Viswanathan, Kishore, Ononye, Sophia N., Cooper, Harold D., Kyle Hadden, M., Anderson, Amy C., Wright, Dennis L.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 642 KB

english, 2012

18

A Structural Approach to Identify a Lead Scaffold that Targets the Translesion Synthesis Polymerase Rev1

Dash, Radha Charan, Ozen, Zuleyha, Rizzo, Alessandro A., Lim, Socheata, Korzhnev, Dmitry M., Hadden, M. Kyle

Journal:

Journal of Chemical Information and Modeling

Year:

2018

Language:

english

File:

PDF, 1.23 MB

english, 2018

19

Structure-Activity Relationships for Itraconazole-Based Triazolone Analogues as Hedgehog Pathway Inhibitors

Pace, Jennifer, Teske, Kelly A., Chau, Lianne, Dash, Radha Charan, Zaino, Angela M., Wechsler-Reya, Robert, Hadden, M. Kyle

Journal:

Journal of Medicinal Chemistry

Year:

2019

Language:

english

File:

PDF, 753 KB

english, 2019

20

Methyllysine binding domains: Structural insight and small molecule probe development

Teske, Kelly A., Hadden, M. Kyle

Journal:

European Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 2.34 MB

english, 2017

21

Structure-Activity Relationships for Itraconazole-Based Triazolone Analogues as Hedgehog Pathway Inhibitors

Pace, Jennifer, Teske, Kelly A., Chau, Lianne, Dash, Radha Charan, Zaino, Angela M., Wechsler-Reya, Robert, Hadden, M. Kyle

Journal:

Journal of Medicinal Chemistry

Year:

2019

File:

PDF, 753 KB

2019

22

Comparison of N-Terminal Modifications on Neurotensin(8−13) Analogues Correlates Peptide Stability but Not Binding Affinity with in Vivo Efficacy

Orwig, Kevin S., Lassetter, McKensie R., Hadden, M. Kyle, Dix, Thomas A.

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 594 KB

english, 2009

23

Vitamin D3 analogues that contain modified A- and seco-B-rings as hedgehog pathway inhibitors

DeBerardinis, Albert M., Raccuia, Daniel S., Thompson, Evrett N., Maschinot, Chad A., Kyle Hadden, M.

Journal:

European Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 11.27 MB

english, 2015

24

Structure-Activity Relationship Studies of Vitamin D3 Analogues Containing an Ether or Thioether Linker as Hedgehog Pathway Inhibitors

Wen, Jiachen, Hadden, M. Kyle

Journal:

Year:

2018

Language:

english

File:

PDF, 747 KB

english, 2018

25

Structure–Activity Relationships for Side Chain Oxysterol Agonists of the Hedgehog Signaling Pathway

Corman, Audrey, DeBerardinis, Albert M., Hadden, M. Kyle

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 372 KB

english, 2012

26

Hedgehog Pathway Agonism: Therapeutic Potential and Small-Molecule Development

Hadden, M. Kyle

Journal:

Year:

2014

Language:

english

File:

PDF, 584 KB

english, 2014

27

Probing the Protein-Protein Interaction between the ATRXADD Domain and the Histone H3 Tail

Zaino, Angela M., Dash, Radha Charan, Hadden, M. Kyle

Journal:

Year:

2020

File:

PDF, 1.11 MB

2020

28

Introduction to Medicinal Chemistry: A Five-Day Course for High School Students

Hadden, M. Kyle, Zaino, Angela M.

Journal:

Journal of Chemical Education

Year:

2020

File:

PDF, 2.03 MB

2020

29

ChemInform Abstract: The Furan Route to Tropolones: Probing the Antiproliferative Effects of β-Thujaplicin Analogues.

Oblak, E. Zachary, Bolstad, Erin S. D., Ononye, Sophia N., Priestley, Nigel D., Hadden, M. Kyle, Wright, Dennis L.

Journal:

Year:

2013

File:

PDF, 33 KB

2013

30

Structure–Activity Relationships for Side Chain Oxysterol Agonists of Hedgehog Signaling

Corman, Audrey, DeBerardinis, Albert M., Hadden, M. Kyle

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

File:

PDF, 161 KB

2013

31

Targeting GLI proteins in human cancer by small molecules (WO2014116651 A1): a patent evaluation

Journal:

Expert Opinion on Therapeutic Patents

Year:

2015

Language:

english

File:

PDF, 329 KB

english, 2015

32

Targeting the Translesion Synthesis Pathway for the Development of Anti-Cancer Chemotherapeutics

Korzhnev, Dmitry M., Hadden, M. Kyle

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 5.43 MB

english, 2016

33

Cover Picture: Synthesis and Evaluation of Osteogenic Oxysterols as Hedgehog Pathway Activators (ChemMedChem 7/2016)

Maschinot, Chad A., Corman, Audrey R., DeBerardinis, Albert M., Hadden, M. Kyle

Journal:

Year:

2016

File:

PDF, 1.10 MB

2016

34

Small molecule scaffolds that disrupt the Rev1-CT/RIR protein-protein interaction

Ozen, Zuleyha, Dash, Radha C., McCarthy, Kaitlyn R., Chow, Samantha A., Rizzo, Alessandro A., Korzhnev, Dmitry M., Hadden, M. Kyle

Journal:

Bioorganic & Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 1.86 MB

english, 2018

35

Identification of Small Molecule Hes1 Modulators as Potential Anticancer Chemotherapeutics

Sail, Vibhavari, Hadden, M. Kyle

Journal:

Chemical Biology & Drug Design

Year:

2013

Language:

english

File:

PDF, 901 KB

english, 2013

36

In Vitro Analysis of Stable, Receptor-Selective Neurotensin[8−13] Analogues

Kokko, Kyle P., Hadden, M. Kyle, Orwig, Kevin S., Mazella, Jean, Dix, Thomas A.

Journal:

Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 96 KB

english, 2003

37

Synthesis and Evaluation of Osteogenic Oxysterols as Hedgehog Pathway Activators

Maschinot, Chad A., Corman, Audrey R., DeBerardinis, Albert M., Hadden, M. Kyle

Journal:

Year:

2016

Language:

english

File:

PDF, 816 KB

english, 2016

38

In vivo behavioral effects of stable, receptor-selective neurotensin[8–13] analogues that cross the blood–brain barrier

Kyle P. Kokko, M. Kyle Hadden, Kimber L. Price, Kevin S. Orwig, Ronald E. See, Thomas A. Dix

Journal:

Neuropharmacology

Year:

2005

Language:

english

File:

PDF, 242 KB

english, 2005

39

Analogues of the Inhoffen–Lythgoe diol with anti-proliferative activity

DeBerardinis, Albert M., Lemieux, Steven, Hadden, M. Kyle

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 596 KB

english, 2013

40

A molecular dynamics approach to identify an oxysterol-based hedgehog pathway inhibitor

Dash, Radha Charan, Maschinot, Chad R., Hadden, M. Kyle

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

2016

Language:

english

File:

PDF, 958 KB

english, 2016

41

Synthesis and evaluation of Hsp90 inhibitors that contain the 1,4-naphthoquinone scaffold

M. Kyle Hadden, Stephanie A. Hill, Jason Davenport, Robert L. Matts, Brian S.J. Blagg

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 255 KB

english, 2009

42

Asymmetric Synthesis of ω‐Bromo‐2(S)‐Methyl Acids as Precursors for Novel Arginine, Lysine, and Mercapto Residues

Hadden, M. Kyle, Kokko, Kyle P., Dix, Thomas A.

Journal:

Synthetic Communications

Year:

2005

Language:

english

File:

PDF, 108 KB

english, 2005

43

Virtual Pharmacophore Screening Identifies Small Molecule Inhibitors of the Rev1‐CT/RIR Protein‐Protein Interaction

Dash, Radha C., Ozen, Zuleyha, McCarthy, Kaitlyn R., Chatterjee, Nimrat, Harris, Cynthia A., Rizzo, Alessandro A., Walker, Graham C., Korzhnev, Dmitry M., Hadden, Matthew Kyle

Journal:

Year:

2019

Language:

english

File:

PDF, 1.63 MB

english, 2019

44

Truncated Itraconazole Analogues Exhibiting Potent Anti-Hedgehog Activity and Improved Drug-like Properties

Wen, Jiachen, Chennamadhavuni, Divya, Morel, Shana R., Hadden, M. Kyle

Journal:

ACS Medicinal Chemistry Letters

Year:

2019

Language:

english

File:

PDF, 322 KB

english, 2019

45

Small molecules block the interaction between porcine reproductive and respiratory syndrome virus and CD163 receptor and the infection of pig cells

Huang, Chang, Bernard, Denzil, Zhu, Jiaqi, Dash, Radha Charan, Chu, Alexander, Knupp, Alec, Hakey, Anna, Hadden, M. Kyle, Garmendia, Antonio, Tang, Young

Journal:

Virology Journal

Year:

2020

File:

PDF, 4.23 MB

2020

46

Oncoepigenomics: Making histone lysine methylation count

DeCarlo, Daniel, Hadden, M. Kyle

Journal:

European Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 615 KB

english, 2012

47

Geldanamycin, Radicicol, and Chimeric Inhibitors of the Hsp90 Nterminal ATP Binding Site

Kyle Hadden, M., Lubbers, Donna, J. Blagg, Brian

Journal:

Current Topics in Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 160 KB

english, 2006

48

Targeting the GLI Family of Transcription Factors for the Development of Anti-Cancer Drugs

Dusek, Christopher, Hadden, M Kyle

Journal:

Expert Opinion on Drug Discovery

Year:

2020

File:

PDF, 1.16 MB

2020

49

Cytotoxic small molecule dimers and their inhibitory activity against human breast cancer cells

M. Kyle Hadden, Brian S.J. Blagg

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 140 KB

english, 2007

50

Exploring the physicochemical and antiproliferative properties of biaryl-linked [13]-macrodilactones

Chen, Chengsheng, Bosko, Cristin, McGeough, Catherine, McLean, Ryan, Zaino, Angela M., Kyle Hadden, M., Peczuh, Mark W.

Journal:

Bioorganic & Medicinal Chemistry

Year:

2020

File:

PDF, 644 KB

2020

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